無創無束縛鼠肺功能WBP全身體積描記系統產品描述

塔望科技研發的無創無束縛鼠肺功能WBP全身體積描記系統（whole-body plethysmograph，WBP）可對清醒自由活動動物呼吸參數進行測量，如呼吸頻率，潮氣量，氣道高反應性測試（Airway hyperresponsiveness，AHR）等。測試過程中，動物可以處于清醒自由狀態，避免了創傷性氣管切開及麻醉的影響，使實驗過程更加簡便，用于呼吸系統模型動物對藥物等反應性研究，呼吸性藥物的藥理和毒理學研究，特別適合于大批量動物快速初篩試驗，適合長期跟蹤研究和重復性篩查。

無創無束縛鼠肺功能WBP全身體積描記系統產品特點

· 不需要做手術，操作簡單

· 可多通道同時監測

· 可在動物在自然狀態下呼吸的研究以及長期跟蹤實驗，適合進行藥物初篩

· 具有藥物氣溶膠霧化模塊

· 具有自動標定功能

· 具有飲水口和食物口，可進行長期連續監測

· 可選配測量心電、血壓、體溫、心率等指標，可與植入式遙測設備聯合使用

· 具有分析軟件，數據可保存至excel或txt格式

無創無束縛鼠肺功能WBP全身體積描記系統可選配的功能模塊：

· 同步視頻監測：同步的視頻錄像文件

· 咳嗽檢測：通過軟件自動監測咳嗽事件

· 其它生理指標測量：可在麻醉或清醒狀態下測量心電、血壓、體溫、心率等指標，可與植入式遙測設備聯合使用

無創無束縛鼠肺功能WBP全身體積描記系統檢測參數

Ti：吸氣時間（s）

Te：呼氣時間（s）

PIF：最大吸氣流速（ml/s）

PEF：最大呼氣流速（ml/s）

Volbal：吸氣時間/呼氣時間

F：呼吸頻率（次/min）

Vt：潮氣量（ml）

Mv：分鐘通氣量（ml）

AV：累積體積（ml）

EF50：呼出50%氣量時對應的呼氣流速（ml/s）

EIP：吸氣峰值壓力（僅在侵入式法測量時有效）

EEP：呼氣峰值壓力（僅在侵入式法測量時有效）

TR：松弛時間

PenH：增強呼氣間歇（enhanced pause）

Rpef：相對時間

無創無束縛鼠肺功能WBP全身體積描記系統適用領域

• 各種呼吸疾病研究，如：哮喘、肺纖維化、肺損傷、ARDS、肺癌等

• 安全藥理：藥物對呼吸系統的影響

• 睡眠呼吸：監測動物低通氣、阻塞性呼吸暫停等

• 環境毒理：環境污染物對動物呼吸的影響
  

• 吸入式毒理：染毒物質對呼吸系統的毒性影響

• 高原醫學：高原環境對呼吸系統的影響

• 其它需要對呼吸參數評價的場合

無創無束縛鼠肺功能WBP全身體積描記系統型號說明

無創無束縛鼠肺功能WBP全身體積描記系統用戶名單

• 上海市中心醫院	瑞金醫院	復旦大學附屬華山醫院	上海藥物所
  中國藥科大學	廣東藥科大學	重慶醫科大學	成都市第三人民醫院
  北京中醫藥大學	中科院城市環境研究所	南京大學	四川大學華西醫院
  蘇州大學	中醫藥大學	安徽醫科大學第一附屬醫院	青島市市立醫院
  蘭州大學	南華大學	寧夏醫科大學	......

無創無束縛鼠肺功能WBP全身體積描記系統

相關文獻

[1]Sun Lingna, Fan Mingrui, Huang Dong, Li Bingqin, Xu Ruoting, Gao Feng, Chen Yanzuo. "Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis" [J]. Biomaterials,  2021

[2]李寧, 李紅鵬, 張本炎, 張柳, 沈繼敏, 李慶云. "高脂膳食對小鼠呼吸功能和膈肌纖維的影響及其線粒體機制" [J]. 中華醫學雜志,  2021,101(36):2893-2899.

[3]Xiong Jiaying,  Zhuang Tao, Ma Yurong,  Xu Junyi, Ye Jiaqi, Ma Ru, Zhang Shuang, Liu Xin, Liu Bi-Feng, Hao Chao,  Zhang Guisen,  Chen Yin. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain" [J]. European Journal of Medicinal Chemistry, 2021, 226:

[4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, " Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance" [J].Frontiers, 2022.819728:

[5]Yumei Zhou, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, "Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma" [J].Frontiers, 2022. 819747:

[6]Zheng R, Yang W, WenYet al. "Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening"  [J].Cell Death Dis 13, 559 (2022)

[7]Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X. "Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy"  [J].PeerJ 10:e13632

[8]Dongyi Zhu, Qian Zhang, Qinchuan Li, Guangxue Wang, Zhongliang Guo. "Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway" [J].The Journal of Gene Medicine, Volume24/Issue9/September 2022/e3442

[9]Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J].Aging CellVolume 21, Issue 8 e13680

[10]Yapeng, LuPanpanChang, WangwangDing, JiangpeiBian, DanWang, XuetingWang, QianqianLuo, XiaomeiWu, LiZhu. "Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells" [J].European Journal of Pharmacology, Volume 929, 15 August 2022, 175137

[11]Mengjun Zhanga, Huiyang Jiang, Lan Wu,  Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang. "Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment" [J]. Journal of Controlled Release, Volume 352

[12]Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui. Zhao, Hua Wang, De-Xiang Xu. "Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice" [J]. Environmental Pollution, Volume 315, 120462

[13]Gu W, Lei J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma [J].Mol Biol Rep 49, 9283–9296 (2022).

[14]Hu M, Yang J, Xu Y, Liu J. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational and Mathematical Methods in Medicine  [J]. Hindawi Computational and Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages

[15]WenJing Wang , Xue Lu , Zhao Li , Kun Peng , Ping Zhan , Lin Fu , Yan Wang , Hui Zhao , Hua Wang , De-Xiang Xu , Zhu-Xia Tan."Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice"[J] Ecotoxicology and Environmental Safety 255 (2023) 114799

[16]Zhou Y, Hu L, Zhang H, Zhang H, Liu J, Zhao X, Wang J, Wang Q."Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells."[J].Frontiers in Pharmacology, 14 Oct 2022, 13:978421

[17]Bao XC, Wang N, Xu J, Ma J and Fang Y-Q (2023) “Effects of different simulated submarine escape depths by free ascent in animal models. “[J]Front. Physiol. 14:1107782.

[18]Haiyun Chen, Qiuyi Wang, Jie Li, Yuan Li, Ao Chen, Jiawen Zhou, Jingyu Zhao, Zhiyuan Mao, Zihao Zhou, Yue Wang, Rong Wan, Qing Li, Yongjie Zhang, Runqiu Jiang,Dengshun Miao, Jianliang Jin, “IFN Transcribed by IRF1 in CD4 + Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis" [J]. Aging and Disease, DOI: 10.14336/AD.2023.0320

[19]崔淦，李琦，舒方方，王汛江，李亞娟，楊莉，王崢濤，丁麗麗. "三七總皂苷通過抑制 NF-κB 轉錄活性改善 LPS 誘導小鼠急性肺損傷的研究". [J]. 藥學學報. DOI： 10.16438/j.0513-4870.2022-0591

[20]IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice Dan Yang, Yi'na Li, Ting Liu, Ling Yang, Lixiu He, Tingxuan Huang, Lanlan Zhang, Jian Luo, Chuntao Liu 。First published: 29 March 2023 13644   Jian Luo and Chuntao Liu contributed equally to this study.

[21]Meihao Peng, Jintao Li, Jie Zhou, Bowen Zhang, Jiaqing Liao, Di Yang, Yu Wang, Yixi Yang, Rui Li, Xue Tang, Qiuxia Lu, Qi Zhao,Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca2+/NFAT pathway,Phytomedicine,2023,154946,ISSN 0944-7113,2023.154946.

[22]Liu, Shengbin and Xiong, Anying and He, Xiang and Qin, Ran and Zhang, Lei and Luo, Li and Wang, Junyi and Jiang, Manling and Liu, Yao and Niu, Bin and Li, Guoping, Fine Particulate Matter Injury Airway Barrier Through Oxidative Stress Promotes the Demethylase FTO Regulating IKKβ m6A Modification and NF-κB Activation in Asthma (5/6/2022).

[23]Xiaoqi Hu, Jingran Su, Mo Chen, Yikun Tu, Chunyan Wu, Xue Cao, Xinyi Yuan, Fang Zhang, Wenjun Ding,Macrophage-derived exosomal TNF-α promotes pulmonary surfactant protein expression in PM2.5-induced acute lung injury,Science of The Total Environment,Volume 892,2023,164732,ISSN 0048-9697,2023.164732.

[24]Ruan, D.; Yang, J.; Luo, Q.; Shi, Y.; Ding, L.; Wang, Z.; Wang, R.; Yang, L. The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition. Molecules 2023, 28, 2883.

[25]Biological Hyperthermia-Inducing Nanoparticles for Specific Remodeling of the Extracellular Matrix Microenvironment Enhance Pro-Apoptotic Therapy in Fibrosis。Jinru Zhang, Keqin Ji, Yuanmeng Ning, Lingna Sun, Mingrui Fan, Chunjie Shu, Ziqi Zhang, Tianyu Tu, Jingyun Cao, Feng Gao, and Yanzuo Chen  ACS Nano 2023 17 (11), 10113-10128   DOI: 10.1021/acsnano.2c12831

[26]Yize Yin,Chaohui Mu,Jiahui Wang,Yixuan Wang, Wenmin Hu,Wenjing Zhu,Xinjuan Yu,Wanming Hao,Yuxin Zheng, Qinghai Li, Wei Han. CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function,[J]2023-07-26,DOI: 10.3390/toxics11080646

[27]Gao-Xiang Wang,Jie Zhou,You-Mou Chen,Liang-Dong Xu,Shan-Ming Tao,Jia Ma,Ye-Han Sun,Ming-Sheng Wu,Zheng-Wei Chen,Yong-Fu Zhu,Ming-Ran Xie,Mechanism of electroacupuncture at acupoints of the lung meridian through PKA/PKC regulation of TRPV1 in chronic cough after lung surgery in guinea pigs,[J]PMC 2023 Apr 28; 15(4): 1848–1860.DOI:10.21037/jtd-23-409

[28]Yang Liu, Amei Tang, Ming Liu, Changjun Xu, Feng Cao, Changfu Yang,Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis,[J]Journal of Ethnopharmacolog，2023-08-01 ,DOI:10.1016/j.jep.2023.116983